The Center for Translational Injury Research (CeTIR) at UTHealth Houston is conducting upcoming clinical trials aimed at advancing trauma care. These studies focus on improving resuscitation techniques and enhancing blood clotting strategies to reduce complications and improve patient outcomes. Through innovative research, CeTIR continues to explore new approaches to trauma treatment that can save lives and improve recovery for critically injured patients.
| Criteria for Re-triage to Improve Trauma Induced Coagulopathy and hemorrhage Associated Lethality (CRITICAL) |
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| Site PI – Michael Wandling, MD |
| Supporting Agency - NIH via Northwestern University |
| Our overarching aim is to enhance care of patients suffering from trauma-induced hemorrhage and trauma-induced coagulopathy by optimizing access to hemostatic resuscitation and hemorrhage control. This proposal seeks to generate which clinical markers indicate severe trauma-induced hemorrhage and trauma-induced coagulopathy that could prompt timely re-triage for hemostatic resuscitation and hemorrhage control. The integration of Electronic Health Records (EHR) in large health systems now enables unprecedented early identification of coagulopathy such as International Normalized Ratio, platelet function assays, and conditions that worsen coagulopathy such as acidemia and severe traumatic brain injuries. EHR data have never before been used to identify who derives greatest survival benefit from re-triage for hemostatic resuscitation. We posit identifying these clinical markers into re-triage criteria can improve recognition and management of trauma-induced hemorrhage and trauma-induced coagulopathy |